Vitamin C, also known as L-ascorbic acid, is a water-soluble vitamin that is naturally present in some foods, added to others, and available as a dietary supplement. Int J Vitam Nutr Res. If you regularly take aspirin or NSAIDs, talk to your doctor before taking more than the recommended daily allowance of vitamin C. Acetaminophen (Tylenol) Vitamin D is essential to maintaining a healthy immune system and strong bones. In recent follow-up studies, no effect was found with doses of vitamin C up to 1,000 mg per day. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. There is concern that use of antioxidants, such as vitamin C, during chemotherapy might reduce the drug's effect. In addition, high doses of vitamin C can cause more of these drugs to … -- There have been rare reports of vitamin C interfering with the effectiveness of this blood thinning medication. Usually avoid combinations; use it only under special circumstances. ... J. D. Interaction of vitamin C and iron. This is a fact sheet intended for health professionals. Applies to: G-6-PD Deficiency. If you take nitrate medications, talk to your doctor about whether you should take vitamin C. Oral contraceptives (birth control pills) and hormone replacement therapy (HRT) Protease inhibitors When given parenterally, utilization of the vitamin reportedly is best after IM administration and that is the preferred parenteral route. This can be harmful for people with kidney problems. This systematic review of the literature was conducted to evaluate the extent to which drugs affect vitamin D status or supplementation alters drug effectiveness or toxicity in humans. Applies to: Nephrolithiasis. Possible Interactions with: Vitamin A (Retinol). Vitamin C and Drug Interactions. In addition, high doses of vitamin C can cause more of these drugs to stay in the body, raising the levels in your blood. Selenium. Moderate Potential Hazard, Low plausibility. Estrogen.Taking vitamin C with oral contraceptive or hormone replacement therapy might increase your estrogen levels. Moderately clinically significant. There are 4 disease interactions with Vitamin C (ascorbic acid): Moderate Potential Hazard, Moderate plausibility. Some very early research suggests that vitamin C might help protect against stomach upset that aspirin and NSAIDs can cause. 20 mg. Interactions Individual interactants: Because of this, there is a potential for interactions with some common drugs. Ascorbic acid should be administered cautiously and dosages modified in patients with G6PD. Common interactions include drug ineffective among females and fatigue among males. The B12 in food is unavailable until the acid and enzymes in the stomach release it from its bound form. The study is created by eHealthMe based on reports of 2,404 people who take Vitamin c and Lipitor from the FDA, and is updated regularly. -- Barbiturates may decrease the effects of vitamin C. These drugs include phenobarbital (Luminal), pentobarbital (Nembutal), and seconobarbital (Seconal). Increases absorption of non-heme iron, even in the presence of inhibitory substances; vitamin C also regulates uptake and metabolism of iron. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Ascorbic acid (vitamin c) is usually administered orally. Possible interactions include: 1. Oral estrogens can also decrease the effects of vitamin C in the body. Vitamin C (ascorbic acid) drug interactions. -- Both aspirin and NSAIDs can lower the amount of vitamin C in the body because they cause more of the vitamin to be lost in urine. Aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) -- Both aspirin and NSAIDs can lower the amount of vitamin C in the body because they cause more of the vitamin to be lost in urine. Select one or more newsletters to continue. Drug interactions are reported among people who take Doxycycline and Vitamin c. Common interactions include renal failure among females and chronic kidney disease among males. Micronutrient Interactions with other minerals or vitamins Interactions Symbol … The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Whenever two or more drugs are being taken, there is a chance that there will be an interaction among the drugs. Vitamin B-12 is also added to some foods and is available as an oral supplement. 1999;69:3173-178. Drug interactions overview Ascorbic acid may decrease effects of erythromycin, kanamycin, streptomycin, doxycycline, and lincomycin; if antibiotic efficacy is suspected, discontinue ascorbic acid Limited case reports have suggested interference of ascorbic acid with anticoagulation effects of warfarin; monitor Drug interactions are reported among people who take Tamsulosin and Vitamin c. Common interactions include headache among females and fatigue among males. -- The combination of vitamin C with nitroglycerin, isosorbide dinitrate (Isordil), or isosorbide mononitrate (Ismo) reduces the body's tendency to build up a tolerance to these medications so that they no longer work. Aspirin may lower vitamin C level in blood, tissue and white blood-cells. -- High doses of vitamin C may lower the amount of acetaminophen passed in urine, which could cause the levels of this drug in your blood to rise. Therefore, people who take several drugs are at the greatest risk for interactions. Drug interactions are reported among people who take Vitamin c and Lipitor. The study is created by eHealthMe based on reports of 4,521 people who take Vitamin c and Omeprazole from the FDA, and is updated regularly. There are 4 disease interactions with Vitamin C (ascorbic acid) which include: hemolysis; kidney stones; sodium; dialysis Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Barbiturates Some of the medicines that may lead to vitamin C drug interactions include: Aluminum products (including many antacids ), such as Mylanta ® Chemotherapy Estrogens, including hormone replacement therapy ( HRT) and hormonal contraceptives (such as birth control pills) Protease inhibitors, such as: © 1997-. -- As an antioxidant, vitamin C may interfere with the effects of some drugs taken for chemotherapy; however, some researchers speculate that vitamin C might help make chemotherapy more effective. Drug interactions are reported among people who take Vitamin c and Coq10. multivitamin, biotin, ascorbic acid, calcium / vitamin d, Fish Oil, Zinc, Ester-C, K-Phos Neutral, PHOS-NaK. Nitrate medications for heart disease Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Possible interactions include: 1. But taking vitamin C along with the antidepressant drug citalopram does not reduce depression symptoms in adults better than citalopram alone. Vitamin B-12 (cobalamin) is a water-soluble vitamin that plays essential roles in red blood cell formation, cell metabolism, nerve function and the production of DNA.Food sources of vitamin B-12 include poultry, meat, fish and dairy products. Vitamin B12. Megadoses can interfere with absorption of vitamin B12. A diet high in vitamin C led to increased percent of absorption of sodium selenite and retention of the absorbed selenium. Vitamin B6 deficiency also weakens your immune system. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Schumann K. Interactions between drugs and vitamins at advanced age. USES: Ascorbic acid (vitamin C) is used to prevent or treat low levels of vitamin C in people who do not get enough of the vitamin from their diets.Most people who eat a normal diet do not need extra ascorbic acid. -- Vitamin C can cause a rise in estrogen levels when taken with these drugs, particularly if you are deficient in vitamin C to begin with and start taking supplements. "Product Information. 5 drops daily, 5 drops contain vitamin A approx. Drug interactions contribute to the cost of healthcare because of the costs of medical care that are required to treat probl… If you are undergoing chemotherapy, do not take vitamin C or any other supplement without talking to your oncologist. Large doses of ascorbic acid have lead to hyperoxaluria in 5% of patients. content is best viewed in IE9 or above, Firefox and Google Chrome browser. Aluminum. Common side effects may include: heartburn, upset stomach; or nausea, diarrhea, stomach cramps. Vitamin B6 deficiency can induce anemia, abnormal brain activity, mood disorders, muscle twitching and seizures (see references 5). There is 1 alcohol/food interaction with Vitamin C (ascorbic acid) Take large doses of vitamin C in divided amounts because the body uses only what is needed at a particular time and excretes the rest in urine. Smith EC. BRAND NAME(S): Cecon, Vitamin C. Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage. Omray A. 4. 3. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Vitamin C (ascorbic acid) drug interactions. Abbott Pharmaceutical, Abbott Park, IL. Most people who eat a normal diet do not need extra ascorbic acid. Clinical monitoring of urinalysis for pH and crystal formation is recommended. Taking vitamin C with oral contraceptive or hormone replacement therapy might increase your estrogen levels. 3. Ascorbic acid should be administered cautiously and dosages modified in patients predisposed to renal stones. Chemotherapy. Conditions: a high amount of oxalic acid in urine iron metabolism disorder causing increased iron storage sickle cell anemia anemia from pyruvate kinase and G6PD deficiencies Applies to: hemodialysis, There are 27 drug interactions with Vitamin C (ascorbic acid), There is 1 alcohol/food interaction with Vitamin C (ascorbic acid). Look up a drug to see which other drugs it interacts with and how serious those interactions are. -- Vitamin C can increase the amount of aluminum your body absorbs, which could cause the side effects of these medications to be worse. Aluminum-containing antacids include Maalox and Gaviscon. Avoid combinations; the risk of the interaction outweighs the benefit. Vitamin B12 is probably the most well-known nutrient to interact with the drug Metformin. Some evidence suggests that taking vitamin C with the antibiotic tetracycline may increase the levels of this medication; it may also decrease the effects of vitamin C in the body. Learn about drug interactions between ascorbic acid oral and aspirin-acetaminophen oral and use the RxList drug interaction checker to check drug combinations. -- Vitamin C appears to slightly lower levels of indinavir (Crixivan), a medication used to treat HIV and AIDS. It might also be useful in preventing many chronic diseases including cancer 1.Vitamin D regulates the amount of minerals such as calcium in the body 1. For a reader-friendly overview of Vitamin C, see our consumer fact sheet on Vitamin C.. Introduction. Taking an aspirin a day to prevent heart attacks and strokes causes blood loss via the digestive tract on the order of about a tablespoon per day which results in iron loss. 2. Vitamin C can increase the side effects of estrogens and decrease the effectiveness of fluphenazine, cancer medications, AIDS medications and cholesterol-lowering medications. A.D.A.M. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. Reviewed By: Steven D. Ehrlich, N.M.D., private practice specializing in complementary and alternative medicine, Phoenix, AZ. Aspirin (Acetylsalicylic acid). Warfarin (Coumadin) Aluminum.Taking vitamin C can increase your absorption of aluminum from medications containing aluminum, such as phosphate binders. 2. Available for Android and iOS devices. Vitamin B6 can diminish the activity of these following medications: levodopa, for Parkinson’s disease, and phenytoin, for seizures (see references 5). Evaluation of pharmacokinetic parameters of tetracylcine hydrochloride upon oral administration with vitamin C and vitamin B complex. The study is created by eHealthMe based on reports of 1,053 people who take Vitamin c and Coq10 from … 300 units (7.5 micrograms), ascorbic acid approx. Estrogen. Minimally clinically significant. Iron. 1981;23(VI):33-37. Ascorbic acid can acidify urine resulting in precipitation of urate, cystine, or oxalate stones. Note: Vitamin C increases the absorption of iron when taken at the same time as iron-rich foods. Content is best viewed in IE9 or above, Firefox and Google Chrome browser. Minor Potential Hazard, High plausibility. The study is created by eHealthMe based on reports of 650 people who take Doxycycline and Vitamin c from the FDA, and is updated regularly. Hindustan Antibiot Bull. Common interactions include rash among females and fatigue among males. Acute hemolysis following administration of high doses of ascorbic acid in patients with glucose-6-phosphate deficiency (G6PD) has been reported. Highly clinically significant. Review provided by VeriMed Healthcare Network. Chemotherapy drugs However, if you take warfarin or another blood thinner, talk to your doctor before taking vitamin C or any other supplement. We comply with the HONcode standard for trustworthy health information -. Yet, the potential for drug-vitamin D interactions is rarely considered. 4. Ascorbic acid preparations contain sodium. Aluminum-containing antacids The sodium content should be considered when used in patients with sodium restricted diets and conditions require sodium restriction, such as congestive heart failure, hypertension, and fluid retention. Ascorbic Acid is used to prevent or treat low levels of vitamin C in people who do not get enough of the vitamin from their diets. The interaction may increase or decrease the effectiveness of the drugs or the side effects of the drugs. Cemill (ascorbic acid)." This can be harmful for people with kidney problems. Low levels of vitamin C can result in a condition called scurvy.Scurvy may cause symptoms such as rash, muscle weakness, joint pain, tiredness, or tooth loss. Tetracycline -- Once free, B12 combines with a substance known as intrinsic factor and is absorbed from the intestines into the bloodstream. Taking vitamin C can increase your absorption of aluminum from medications containing aluminum, such as phosphate binders. The likelihood of drug interactions increases as the number of drugs being taken increases. Vitamin C can also have minor interactions with Tylenol, aspirin, choline magnesium trisalicylate, nicardipine, nifedipine and salsalate, according to MedlinePlus 4. DOSAGE AND ADMINISTRATION. The study is created by eHealthMe based on reports of 1,065 people who take Tamsulosin and Vitamin c from the FDA, and is updated regularly. 700 units, vitamin D approx. Other antibiotics in the same family include minocycline (Minocin) and doxycycline (Vibramycin). If you are being treated with any of the following medications, you should not use vitamin C supplements without first talking to your health care provider. When oral administration is not feasible or when malabsorption is suspected, the drug may be administered IM, IV, or subcutaneously. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. There are 27 drug interactions with Vitamin C (ascorbic acid) Vitamin C (ascorbic acid) disease interactions. Vitamins and Drug Interactions Vitamin A: Vitamin A is a fat-soluble vitamin found in everyday foods, including liver, yellow-orange fruits and vegetables such as carrots, margarine, milk, and dark green, leafy vegetables such as spinach. Applies to: Hypernatremia, Hypertension. There are 27 drug interactions with Vitamin C (ascorbic acid) Vitamin C (ascorbic acid) alcohol/food interactions. 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